| Goergia Tech | -2.5 | Virginia Tech | Virginia Tech W |
| South Alabama | -1.5 | UL-Lafayette | South Alabama W |
| USC | -16.5 | Colorado | USC L |
| Duke | -3 | Pittsburgh | Duke L |
| Cincinnati | -18 | Tulsa | Tulsa W |
| UTSA | -4 | Charlotte | UTSA L |
| U Mass | -7 | Eastern Michigan | U Mass W |
| Middle Tennessee | -5.5 | FAU | Middle Tennessee W |
| Michigan | -13 | Indiana | Michigan L |
| Marshall | -11.5 | FIU | Marshall W |
| Akron | -7 | Miami (Ohio) | Akron W |
| Michigan State | -14 | Maryland | Michigan State W |
| Houston | -6.5 | Memphis | Memphis W |
| Ohio State | -16 | Illinois | Ohio State W |
| Army | -2.5 | Tulane | Army L |
| Clemson | -28 | Syracuse | Clemson L |
| Temple | -2 | USF | Temple L |
| Nebraska | -9 | Rutgers | Nebraska W |
| Old Dominion | -6 | UTEP | Old Dominion W |
| TCU | -44.5 | Kansas | Kansas W |
| Texas Tech | -5.5 | Kansas State | Texas Tech W |
| Vanderbilt | -3 | Kentucky | Kentucky L |
| Northwestern | -14.5 | Purdue | Northwestern L |
| Florida State | -9 | NC State | Florida State W |
| Utah State | -1 | Air Force | Air Force W |
| Texas State | -2 | Georgia State | Texas State L |
| Arkansas State | -14 | UL-Monroe | Arkansas State W |
| UCLA | -10 | Washington State | Washington State W |
| West Virginia | -8.5 | Texas | West Virginia W |
| Notre Dame | -27 | Wake Forest | Notre Dame L |
| Alabama | -8 | Mississippi State | Mississippi State L |
| North Carolina | -12 | Miami | North Carolina W |
| Southern Miss | -7.5 | Rice | Southern Miss W |
| Navy | -21 | SMU | Navy W |
| Oklahoma State | -14 | Iowa State | Oklahoma State L |
| LSU | -7.5 | Arkansas | LSU L |
| Auburn | -1.5 | Georgia | Auburn L |
| Arizona State | -3 | Washington | Arizona State W |
| Baylor | -2.5 | Oklahoma | Baylor L |
| BYU | -6.5 | Missouri | BYU L |
| Georgia Southern | -6.5 | Troy | Georgia Southern W |
| Nevada | 1 | San Jose State | Nevada W |
| California | -21 | Oregon State | California W |
| Appalachian State | -18 | Idaho | Appalachian State W |
| Colorado State | -7.5 | UNLV | Colorado State W |
| Louisville | -14 | Virginia | Louisville L |
| Utah | -6 | Arizona | Utah L |
| Tennessee | -41.5 | North Texas | Tennessee L |
| Florida | -7 | South Carolina | Florida W |
| Stanford | -9.5 | Oregon | Stanford L |
| Boise State | -30 | New Mexico | New Mexico W |
| Iowa | -12 | Minnesota | Iowa L |
| San Diego State | -24 | Wyoming | San Diego State W |
| Hawaii | -4.5 | Fresno State | Fresno State W |
Thursday, November 12, 2015
Week 11 Picks Against the Spread
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